Key result
In hypertensive rats, treatment with nebivolol combined with 4 weeks of physical training reduced mean arterial pressure compared to sedentary hypertensive controls (P=0.015).
Why the study?
Does nebivolol combined with physical training improve cardiovascular responses in hypertensive rats compared with either intervention alone?
Does nebivolol combined with physical training improve cardiovascular responses in hypertensive rats compared with either intervention alone?
p-value: p=0.015
The combination of nebivolol and physical training provides increased cardiovascular benefits over either intervention alone in a hypertensive rat model.
May support combined nebivolol-exercise effects on blood pressure in rat models; leaves open superiority to monotherapy and human translation.
The aim of this study was to determine whether exercise training combined with beta-blocker treatment promotes additional cardiovascular benefits compared with either intervention on its own. For this we used 76 Wistar rats distributed among different groups: normotensive sedentary (NS), normotensive trained (NT), normotensive sedentary treated with beta-blocker (NS_BB), normotensive trained treated with beta-blocker (NT_BB), hypertensive sedentary (HS), hypertensive trained (HT), hypertensive sedentary treated with a beta-blocker (HS_BB), and hypertensive trained rats treated with beta-blocker (HT_BB). Exercise training consisted of 4 weeks of swimming for 60 min a day, 5 days a week. Hypertension was induced with l-NAME (4 weeks), whereas the control rats received saline, and both the control and test rats received nebivolol. The animals underwent surgery to directly record their blood pressure. The HS group showed higher mean arterial pressure (MAP) (P = 0.000), systolic arterial pressure (P = 0.000), and diastolic arterial pressure (P = 0.000) compared with NS. MAP was higher in the HS compared with the HT (P = 0.002), HS_BB (P = 0.018), and HT_BB (P = 0.015) groups. Hearts from the HS group had a higher percentage of collagen compared with the NS and HS_BB groups. The HT_BB and HT groups only had a higher percentage of cardiac collagen by comparison with the HS_BB group. The HT_BB group showed higher levels of macrophages and neutrophils by comparison with the HT and HS_BB groups. Thus, treatment with a beta-blocker combined with physical training was associated with increased cardiovascular benefits over either intervention alone.
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Goessler et al. (2013) studied Hypertension (n=76). Nebivolol combined with physical training vs. Sedentary control, physical training alone, or nebivolol alone was evaluated on Mean arterial pressure (MAP) (p=0.015). In hypertensive rats, treatment with nebivolol combined with 4 weeks of physical training reduced mean arterial pressure compared to sedentary hypertensive controls (P=0.015).
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