Why the study?
Does the combination of exercise training and bisoprolol improve blood pressure and baroreflex function more than either intervention alone in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHR) starting at 5 weeks of age
Comparison
Exercise training, moderate dose of bisoprolol… vs Sedentary control
Design
Preclinical
Follow-up
12 weeks (from 5 to 17 weeks of age)
Authors
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Similar benefits from exercise or bisoprolol alone without additive effects in rats; hypothesis-generating and should not yet inform clinical practice.
Does the combination of exercise training and bisoprolol improve blood pressure and baroreflex function more than either intervention alone in spontaneously hypertensive rats?
Exercise training and bisoprolol similarly improve resting hemodynamics and baroreflex function in hypertensive rats, with additive effects primarily seen under stress.
Naoki Minami (2003) studied this question.
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