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Thermoresponsive hydrogels based on biodegradable poly(amino acid)s have been developed by crosslinking of poly(N-(ω-hydroxyalkyl) α/β-asparagine)s with diisocyanate. The poly(amino acid) hydrogels showed a thermoresponsive release of a model drug.
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Tachibana et al. (2003) studied this question.
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