February 18, 1972Science

Cytochalasin B: Does It Affect Actin-Like Filaments?

View Full Paper

Ask AI

Bookmark

Why the study?

Does cytochalasin B affect actin-like filaments in vitro?

Population

In vitro system (actin-like filaments, F-actin, G-actin, heavy meromyosin)

Design

Preclinical

Authors

AFArthur ForerYork University JEJ. Emmersem OBO. BehnkeTokyo Dental College

Discussion

Member takes

Implication

Cytochalasin B shows no direct effect on actin filaments in vitro; leaves open cellular mechanisms and requires in vivo validation.

Structured PICO

Does cytochalasin B affect actin-like filaments in vitro?

Population

In vitro system (actin-like filaments, F-actin, G-actin, heavy meromyosin)

Intervention

Cytochalasin B at concentrations 100 times those used for experiments in vivo

Outcome

Breakdown of F-actin, transformation of G-actin to F-actin, binding of heavy meromyosin to F-actin, and adenosine triphosphate-induced release of heavy meromyosin from F-actinsurrogate

Cytochalasin B does not appear to directly affect actin-like filaments in vitro, even at high concentrations.

Cite This Study

Forer et al. (1972) studied this question.

synapsesocial.com/papers/6a8aded1df3a83baf8ca989d https://doi.org/10.1126/science.175.4023.774

View Full Paper

Ask AI

Bookmark

Cytochalasin B: Does It Affect Actin-Like Filaments?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cytochalasin B: Does It Affect Actin-Like Filaments?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider