What does this research mean for the field?

Cytochalasin B directly interacts with the actin moiety of the actomyosin complex at nearly stoichiometric concentrations, decreasing actomyosin viscosity and inhibiting acto-heavy meromyosin ATPase activity. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 1, 1972Proceedings of the National Academy of SciencesOpen Access

Cytochalasin B, Its Interaction with Actin and Actomyosin from Muscle

View Full Paper

Ask AI

Bookmark

Population

Actin and actomyosin from striated muscle

Design

Preclinical

Authors

JSJames A. SpudichHeart Failure & Transplant SLShin LinJohns Hopkins University

Discussion

Member takes

Implication

No immediate clinical implications; leaves open in vivo validation of actin-targeted inhibition.

Structured PICO

Population

Actin and actomyosin from striated muscle

Intervention

Cytochalasin B

Outcome

Viscosity of the actomyosin complex and acto-heavy meromyosin ATPase activitysurrogate

Cytochalasin B interacts directly with actin, inhibiting acto-heavy meromyosin ATPase activity and decreasing actomyosin viscosity, with myosin competing for actin binding.

Cite This Study

Spudich et al. (1972) studied this question.

synapsesocial.com/papers/6a127fa08edbaba0bf676293 https://doi.org/10.1073/pnas.69.2.442

View Full Paper

Ask AI

Bookmark

Cytochalasin B, Its Interaction with Actin and Actomyosin from Muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cytochalasin B, Its Interaction with Actin and Actomyosin from Muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider