Key result
Increased pulmonary blood flow combined with monocrotaline induced specific pulmonary neointimal lesions and the expression of transcription factors ATF3 and EGR-1 in a rat model of PAH.
Population
Rat model of flow-associated pulmonary arterial hypertension (PAH) with neointimal lesions
Comparison
Increased pulmonary blood flow combined with… vs Monocrotaline alone
Design
Preclinical
Authors
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ATF3 and EGR-1 merit investigation as targets in flow-associated PAH remodeling; leaves open translation from this rat model.
Identification of ATF3, EGR-1, and iloprost-responsive pathways in a rat model of flow-associated PAH provides potential new therapeutic targets for pulmonary vascular remodeling.
Albada et al. (2009) studied Pulmonary arterial hypertension. Increased pulmonary blood flow and monocrotaline vs. Monocrotaline alone was evaluated on Gene expression profiles associated with neointimal lesions. Increased pulmonary blood flow combined with monocrotaline induced specific pulmonary neointimal lesions and the expression of transcription factors ATF3 and EGR-1 in a rat model of PAH.
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