Key result
PAH vessel transcriptional profiles were enriched for genes in TGF-b, TNF-a signaling, oxidative stress, apoptosis, and hypoxia pathways compared with control pulmonary arteries.
Population
210 histologic regions of interest from 11 idiopathic pulmonary arterial hypertension and 5 control lungs
Comparison
NanoString GeoMx digital spatial profiling of… vs Control pulmonary arteries
Design
Editorial
Authors
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This editorial highlights the first comprehensive spatial transcriptomic analysis of pulmonary vascular lesions in PAH, revealing distinct molecular signatures and pathway enrichments across lesion types.
This editorial highlights the first comprehensive spatial transcriptomic analysis of pulmonary vascular lesions in PAH, revealing distinct molecular signatures and pathway enrichments across lesion types.
William M. Oldham (2024) conducted an editorial in Pulmonary arterial hypertension (n=16). Pulmonary arterial hypertension vs. Control lungs was evaluated on Gene transcription profiles. PAH vessel transcriptional profiles were enriched for genes in TGF-b, TNF-a signaling, oxidative stress, apoptosis, and hypoxia pathways compared with control pulmonary arteries.
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