What question did this study set out to answer?

This study aims to quantitatively analyze vascular remodeling and pruning in pulmonary arterial hypertension (PAH) using micro-CT imaging.

May 24, 2026

Three-dimensional micro-CT analysis of vascular remodeling and vascular pruning in pulmonary arterial hypertension.

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Randomized trial analyzes vascular remodeling in pulmonary arterial hypertension, highlighting critical alterations in blood vessels.

This study aims to quantitatively analyze vascular remodeling and pruning in pulmonary arterial hypertension (PAH) using micro-CT imaging.
Performed micro-computed tomography (µCT) imaging on explanted lungs from seven PAH patients and five healthy controls.
Quantified arterial lumen diameter, number of acinar vessels, and plexiform lesion distribution.
Correlated findings with clinical and hemodynamic data.
Observed a 50% reduction in the diameter of the acinar arterial lumen.
Found a 61% decrease in the number of intra-acinar arterioles confirming vascular pruning.
Heritable PAH showed significantly more plexiform lesions than idiopathic PAH, indicating a more severe vascular phenotype.

Aerts et al. (2026) studied this question.

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