What is the clinical evidence from this study?

Study design: Editorial. Population: Pulmonary arterial hypertension (n=12). Intervention: End-stage idiopathic or heritable PAH vs. Healthy donor lungs. Primary outcome: Pulmonary vascular remodelling.

What does this research mean for the field?

High-resolution three-dimensional micro-CT enables quantitative characterization of pulmonary vascular remodeling and pruning in end-stage pulmonary arterial hypertension. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Characterize three-dimensional pulmonary vascular remodelling and pruning in end-stage pulmonary arterial hypertension using high-resolution micro-computed tomography.

September 1, 2026European Respiratory Journal

High-resolution 3D micro-CT quantitatively characterizes pulmonary vascular remodeling in end-stage PAH versus healthy lungs.

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Why the study?

Quantitative characterization of pulmonary vascular remodelling in end-stage PAH using high-resolution micro-CT was needed to better understand vascular changes.

Comparison

PAH lungs vs healthy donor lungs

Design

Editorial analysis using high-resolution three-dimensional micro-CT

Key result

High-resolution three-dimensional micro-CT quantitatively characterized pulmonary vascular remodeling in 7 explanted lungs with end-stage PAH compared to 5 healthy donor lungs.

Authors

FRFarbod N. Rahaghi ABAdam J. Brownstein RSRajan Saggar

Discussion

Member takes

Overview

Supports quantitative micro-CT for vascular remodeling in end-stage PAH explants; leaves open translation to earlier disease or clinical use.

Key Points

Characterize three-dimensional pulmonary vascular remodelling and pruning in end-stage pulmonary arterial hypertension using high-resolution micro-computed tomography.
Performed high-resolution three-dimensional micro-computed tomography (micro-CT) on explanted human lung specimens.
Evaluated explanted lungs from patients with idiopathic or heritable pulmonary arterial hypertension (N=7) and compared them with healthy donor lungs (N=5).
Three-dimensional micro-CT quantitatively visualized and mapped vascular remodelling and vascular pruning in end-stage diseased lungs.
High-resolution imaging provided quantitative anatomical data to support multiscale modeling of altered pulmonary hemodynamics.

Structured PICO

Population

12 explanted lungs (7 from patients with idiopathic or heritable PAH and 5 from healthy donors) analyzed using micro-CT.

Exposure

High-resolution three-dimensional micro-computed tomography (micro-CT)

Comparator

Healthy donor lungs

Outcome

Quantitative characterization of pulmonary vascular remodelingsurrogate

High-resolution micro-CT can be used to quantitatively characterize pulmonary vascular remodeling in explanted lungs of patients with end-stage PAH.

Cite This Study

Rahaghi et al. (2026) conducted an editorial in Pulmonary arterial hypertension (n=12). End-stage idiopathic or heritable PAH vs. Healthy donor lungs was evaluated on Pulmonary vascular remodelling. High-resolution three-dimensional micro-CT quantitatively characterized pulmonary vascular remodeling in 7 explanted lungs with end-stage PAH compared to 5 healthy donor lungs.

synapsesocial.com/papers/6aaca6cb89cab5e32db0d992 https://doi.org/10.1183/13993003.01236-2026

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September 1, 2026European Respiratory Journal

High-resolution 3D micro-CT quantitatively characterizes pulmonary vascular remodeling in end-stage PAH versus healthy lungs.

View Full Paper

Ask AI

Bookmark

Why the study?

Quantitative characterization of pulmonary vascular remodelling in end-stage PAH using high-resolution micro-CT was needed to better understand vascular changes.

Comparison

PAH lungs vs healthy donor lungs

Design

Editorial analysis using high-resolution three-dimensional micro-CT

Key result

High-resolution three-dimensional micro-CT quantitatively characterized pulmonary vascular remodeling in 7 explanted lungs with end-stage PAH compared to 5 healthy donor lungs.

Authors

FRFarbod N. Rahaghi ABAdam J. Brownstein RSRajan Saggar

Discussion

Member takes

Overview

Supports quantitative micro-CT for vascular remodeling in end-stage PAH explants; leaves open translation to earlier disease or clinical use.

Key Points

Characterize three-dimensional pulmonary vascular remodelling and pruning in end-stage pulmonary arterial hypertension using high-resolution micro-computed tomography.
Performed high-resolution three-dimensional micro-computed tomography (micro-CT) on explanted human lung specimens.
Evaluated explanted lungs from patients with idiopathic or heritable pulmonary arterial hypertension (N=7) and compared them with healthy donor lungs (N=5).
Three-dimensional micro-CT quantitatively visualized and mapped vascular remodelling and vascular pruning in end-stage diseased lungs.
High-resolution imaging provided quantitative anatomical data to support multiscale modeling of altered pulmonary hemodynamics.

Structured PICO

Population

12 explanted lungs (7 from patients with idiopathic or heritable PAH and 5 from healthy donors) analyzed using micro-CT.

Exposure

High-resolution three-dimensional micro-computed tomography (micro-CT)

Comparator

Healthy donor lungs

Outcome

Quantitative characterization of pulmonary vascular remodelingsurrogate

High-resolution micro-CT can be used to quantitatively characterize pulmonary vascular remodeling in explanted lungs of patients with end-stage PAH.

Cite This Study

synapsesocial.com/papers/6aaca6cb89cab5e32db0d992 https://doi.org/10.1183/13993003.01236-2026

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