Key result
The ACE gene insertion/deletion polymorphism was not significantly associated with Parkinson's disease susceptibility, with the DD genotype present in 39% of cases versus 32% of controls (p=0.6).
Why the study?
Is the ACE gene insertion/deletion polymorphism associated with susceptibility to Parkinson's disease?
Population
77 Parkinson's disease (PD) patients and 50 non-PD controls from Greece
Comparison
ACE gene insertion/deletion (I/D) polymorphism vs Non-PD controls
Design
Case-control
Authors
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No association seen in case-control study; leaves open ACE polymorphism role in Parkinson's susceptibility.
Case-Control (n=127)
Blinded genotyping
Yes
Is the ACE gene insertion/deletion polymorphism associated with susceptibility to Parkinson's disease?
Absolute Event Rate: 39% vs 32%
p-value: p=0.6
The ACE insertion/deletion polymorphism is unlikely to be an important determinant of susceptibility to Parkinson's disease in the Greek population.
Papapetropoulos et al. (2008) conducted a case-control in Parkinson's disease (n=127). ACE gene insertion/deletion (I/D) polymorphism vs. Non-PD healthy controls was evaluated on Distribution of ACE I/D polymorphism genotypes (II, ID, DD) and alleles (p=0.6). The ACE gene insertion/deletion polymorphism was not significantly associated with Parkinson's disease susceptibility, with the DD genotype present in 39% of cases versus 32% of controls (p=0.6).
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