Down's Syndrome. Two Types Distinguished by a Serum Antigen (Australia Antigen).

s1 May 1967Down's Syndrome. Two Types Distinguished by a Serum Antigen (Australia Antigen).Baruch S. Blumberg, M.D., Ph.D., F.A.C.P., Betty Jane S. Gerstley, M.D. (Associate), W. Thomas London, M.D., Alton I. Sutnick, M.D., F.A.C.P.Baruch S. Blumberg, M.D., Ph.D., F.A.C.P.Search for more papers by this author, Betty Jane S. Gerstley, M.D. (Associate)Search for more papers by this author, W. Thomas London, M.D.Search for more papers by this author, Alton I. Sutnick, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1040_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA "new" apparently inherited serum isoantigen, "Australia antigen" (Au(I)), which has not been found in the normal United States population, is present in high frequency in patient's with Down's syndrome and leukemia. Forty-five Down's syndrome patients, of whom 19 had Au(1) and 26 did not (Au(0)), and 10 control mentally retarded patients without Down's syndrome were included in this study.Studies of their immunologic mechanisms revealed distinct differences between patients with and without Down's syndrome. These included lower influenza antibody titers, less reaction to the mumps skin test, and higher gamma-A immunoglobulin levels in Down's syndrome patients. Rebuck skin window... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAUSTRAUA ANTIGEN, AUTOANTmODIES AND CELL‐MEDIATED IMMUNE RESPONSES IN PATIENTS WITH DOWN'S SYNDROMEOCCURRENCE OF AUSTRALIA ANTIGEN IN PATIENTS WITH DOWN'S SYNDROME IN POLAND*Australia Antigen and Hepatitis: A Comprehensive ReviewViral Hepatitis: Revised Concepts as a Result of the Study of Australia AntigenAustralia antigen as a hepatitis virusAustralia antigen and the quest for a hepatitis virus 1 May 1967Volume 66, Issue 5Page: 1040-1040KeywordsAntigensDown syndromeMumpsSkin tests Issue Published: 1 May 1967 PDF downloadLoading ...