Why the study?
Does intravenous angiotensin have a central stimulant action on the sympathetic nervous system compared to noradrenaline in cats and dogs?
Does intravenous angiotensin have a central stimulant action on the sympathetic nervous system compared to noradrenaline in cats and dogs?
In animal models, angiotensin does not exert a central stimulant action on the sympathetic nervous system when raising blood pressure, producing similar sympathetic discharge changes as noradrenaline.
No central sympathetic stimulation by angiotensin in animal models at high BP; leaves open translation to human hypertension mechanisms.
The effects of angiotensin and noradrenaline on discharge frequency in single and few-fibre preparations of the cervical sympathetic nerve of cats and dogs have been compared.2. When equal changes in blood pressure were produced by intravenous infusion of these drugs, the changes found in sympathetic discharge were similar both in anaesthetized animals and in a decerebrate one.3. Angiotensin and noradrenaline also have similar effects on discharge in sympathetic nerve fibres following complete denervation of the baroreceptor and chemoreceptor nerves.4. It is concluded that when the blood pressure is raised to 200 mmHg by angiotensin, the drug has no central stimulant action on the sympathetic nervous system.
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Morrison et al. (1971) studied this question.
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