Key result
Doxorubicin therapy enhanced platelet function, leading to thrombus formation and vascular injury in mice, which was ameliorated by clopidogrel treatment.
Population
Mice
Comparison
Doxorubicin alone vs doxorubicin plus clopidogrel
Design
Animal study
Authors
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Raises possibility of doxorubicin-associated thrombosis; hypothesis-generating for antiplatelet strategies in cardio-oncology.
Key points are not available for this paper at this time.
Lv et al. (2020) studied this question. Doxorubicin therapy enhanced platelet function, leading to thrombus formation and vascular injury in mice, which was ameliorated by clopidogrel treatment.
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