Why the study?
Does Daunorubicin affect platelet function in vitro?
Population
In vitro platelets
Design
Preclinical
Authors
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May contribute to bleeding risk with daunorubicin; leaves open in vivo relevance and clinical translation.
Does Daunorubicin affect platelet function in vitro?
Daunorubicin induces in vitro thrombocytopathy without damaging the cellular membrane at clinical doses, potentially contributing to hemorrhagic diathesis during therapy.
Pogliani et al. (1981) studied this question.
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