Why the study?
Does 24 months of clopidogrel therapy compared to 6 months reduce the composite of death, myocardial infarction, or cerebrovascular accidents in patients undergoing coronary stent implantation?
RCT (n=2,013)
Yes
Does 24 months of clopidogrel therapy compared to 6 months reduce the composite of death, myocardial infarction, or cerebrovascular accidents in patients undergoing coronary stent implantation?
Effect estimate: HR 0.98 (95% CI 0.74-1.29)
Absolute Event Rate: 10.1% vs 10%
p-value: p=0.91
Prolonged dual-antiplatelet therapy (24 months) after stent implantation does not reduce ischemic events compared to 6 months but significantly increases the risk of major bleeding.
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A 2013 study conducted an RCT in Coronary stent implantation (n=2,013). 24-month clopidogrel therapy in addition to aspirin vs. 6-month clopidogrel therapy in addition to aspirin was evaluated on Composite ischemic end point of overall death, myocardial infarction, or cerebrovascular accidents (HR 0.98, 95% CI 0.74-1.29, p=0.91).
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