Key result
Pericardial fluid GDF-15 and NT-pro-BNP levels were increased in atrial fibrillation patients with aortic stenosis and correlated with atrial matrix remodeling markers.
Why the study?
The study aimed to evaluate the association of GDF-15 and NT-pro-BNP across two biological matrices with AF, atrial matrix remodeling, and 30-day postoperative outcomes in severe aortic stenosis patients undergoing AVR.
Are pericardial fluid and serum GDF-15 and NT-pro-BNP associated with atrial fibrillation and atrial matrix remodeling in patients with severe aortic stenosis undergoing AVR?
Observational (n=126)
No
Are pericardial fluid and serum GDF-15 and NT-pro-BNP associated with atrial fibrillation and atrial matrix remodeling in patients with severe aortic stenosis undergoing AVR?
Pericardial fluid GDF-15 and NT-pro-BNP serve as biomarkers for atrial fibrillation and atrial matrix remodeling in patients with severe aortic stenosis, and GDF-15 predicts postoperative acute kidney injury.
Hypothesis-generating for local biomarkers in AF remodeling; leaves open clinical utility pending prospective validation.
AIMS: This study aimed to evaluate the association of GDF-15 and NT-pro-BNP in two different biological matrices with AF in severe aortic stenosis patients undergoing aortic valve replacement surgery (AVR), its association with atrial matrix remodeling, as well as with 30-day postoperative outcomes. MAIN METHODS: One hundred and twenty-six patients between 2009 and 2019 with severe aortic stenosis undergoing AVR surgery in a tertiary hospital were assessed. KEY FINDINGS: pericardial fluid GDF-15 and pericardial fluid and serum NT-pro-BNP were increased in AF patients with aortic stenosis. COL1A1 and COL3A1 gene expression increased when pericardial fluid NT-pro-BNP values were higher. TIMP4 was positively correlated with pericardial fluid GDF-15. SIGNIFICANCE: GDF-15 and NT-pro-BNP in the pericardial fluid are biomarkers of atrial fibrillation in aortic stenosis and correlate with atrial matrix remodeling. AKI is predicted by both serum and pericardial fluid GDF-15.
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Fragão-Marques et al. (2021) conducted an observational in Severe aortic stenosis (n=126). Pericardial fluid GDF-15 and NT-pro-BNP levels was evaluated on Atrial fibrillation and atrial matrix remodeling. Pericardial fluid GDF-15 and NT-pro-BNP levels were increased in atrial fibrillation patients with aortic stenosis and correlated with atrial matrix remodeling markers.
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