Population
Nephrectomy material from 10 patients with chronic renal transplant failure (CRTF) and 10 control kidneys
Design
Case-control
Authors
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Should not change transplant management; leaves open whether iNOS modulation could mitigate chronic renal allograft failure.
Chronic renal transplant failure is associated with increased interstitial iNOS and decreased glomerular eNOS expression, along with increased ROS and nitrotyrosine formation.
Albrecht et al. (2002) studied this question.