Key result
A 56-year-old male presenting with acute pericarditis was diagnosed with lung adenocarcinoma, highlighting the importance of etiological investigation for occult malignancy in atypical presentations.
Case Report (n=1)
Acute pericarditis can serve as an initial presentation of an occult malignancy, underscoring the importance of thorough etiological investigation in atypical or relapsing cases.
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Favorable response to ASA-colchicine seen in comorbid acute pericarditis; leaves open need for prospective data on systemic associations.
Acute pericarditis is the most common pericardial disease, presenting with varied manifestations and potentially indicative of systemic disease. A 56-year-old male with a history of hypertension, dyslipidemia, type 2 diabetes, and a former smoker presented with chest pain relieved by leaning forward, fever, elevated inflammatory markers, and electrocardiographic changes consistent with acute pericarditis. Initial treatment with acetylsalicylic acid and colchicine resulted in a favorable clinical response with improvement in inflammatory markers. However, symptoms later worsened, accompanied by night sweats and weight loss. Imaging revealed a nonspecific pulmonary lesion in the right upper lobe and consolidation in the left lower lobe with associated pleural effusion. Pleural fluid analysis indicated an exudate, predominated by mononuclear cells, with negative cytology. A guided biopsy confirmed lung adenocarcinoma. This case underscores the importance of a holistic approach to acute pericarditis, with an emphasis on etiological investigation in atypical presentations.
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Silva et al. (2025) conducted a case report in Acute pericarditis and Lung adenocarcinoma (n=1). Etiological investigation and oncological treatment (lobectomy and chemotherapy) was evaluated. A 56-year-old male presenting with acute pericarditis was diagnosed with lung adenocarcinoma, highlighting the importance of etiological investigation for occult malignancy in atypical presentations.
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