Key result
A short course of low-dose amiodarone for postoperative atrial fibrillation after CABG resulted in fatal acute lung toxicity with diffuse pulmonary damage.
Case Report (n=1)
Highlights the rare but fatal risk of acute pulmonary toxicity associated with even short-course, low-dose amiodarone used for postoperative atrial fibrillation.
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Short low-dose amiodarone for post-CABG AF may cause fatal pulmonary toxicity; this case leaves incidence and risk factors open.
Amiodarone is one of the commonly used anti-arrhythmic agents with well-recognized chronic pulmonary toxicity. We present our experience of a patient with a fatal outcome after coronary artery bypass grafting and a short course of amiodarone treatment with a low total cumulative dose for the treatment of postoperative atrial fibrillation. Necropsy revealed diffuse pulmonary damage due to acute amiodarone lung toxicity.
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Argyriou et al. (2007) conducted a case report in Postoperative atrial fibrillation (n=1). Amiodarone was evaluated on Acute amiodarone lung toxicity. A short course of low-dose amiodarone for postoperative atrial fibrillation after CABG resulted in fatal acute lung toxicity with diffuse pulmonary damage.
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