What is the clinical evidence from this study?

Study design: Case Report. Population: Amiodarone-induced pulmonary toxicity (n=1). Intervention: Amiodarone. Primary outcome: Fatal pulmonary toxicity.

What does this research mean for the field?

Fatal amiodarone-induced pulmonary toxicity can occur even with long-term low-dose maintenance therapy. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 2016International Journal of Case Reports and ImagesOpen Access

Amiodarone-induced pulmonary toxicity (APT): A low dose fatal adverse event

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Key result

Low-dose amiodarone at 100 mg daily triggers fatal pulmonary toxicity.

Why the study?

Amiodarone pulmonary toxicity can be fatal and occurs even at low doses, posing a diagnostic challenge without specific clinical features.

Design

Case report

Authors

MBMuhammad Imran ButtNHS Highland

Discussion

Member takes

Implication

APT warrants consideration in amiodarone-treated patients with respiratory distress irrespective of dose; single case leaves open need for prospective validation.

Study Design

Type

Case Report (n=1)

Structured PICO

Population

A 49-year-old female with a history of atrial fibrillation, rheumatic heart disease, and pulmonary hypertension who developed fatal amiodarone-induced pulmonary toxicity after taking a low maintenance dose of 100 mg/day for three years.

Exposure

Amiodarone started at an initial dose of 600 mg/day and tapered down to a maintenance dose of 100 mg/day over three weeks, continued for 3 years.

Outcome

Amiodarone-induced pulmonary toxicity (APT) leading to fatal respiratory failure.safety

Amiodarone-induced pulmonary toxicity can be fatal even at low maintenance doses (100 mg/day), highlighting the need for close monitoring in high-risk patients.

Limitations

Lung biopsy was not performed due to the risk involved in the procedure

Cite This Study

Muhammad Imran Butt (2016) conducted a case report in Amiodarone-induced pulmonary toxicity (n=1). Amiodarone was evaluated on Fatal pulmonary toxicity. A 49-year-old female developed fatal amiodarone-induced pulmonary toxicity despite taking a low maintenance dose of 100 mg per day for three years.

synapsesocial.com/papers/6ab8d50905ba373fef2973a4 https://doi.org/10.5348/ijcri-201649-cr-10637

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January 1, 2016International Journal of Case Reports and ImagesOpen Access

Amiodarone-induced pulmonary toxicity (APT): A low dose fatal adverse event

View Full Paper

Ask AI

Bookmark

Key result

Low-dose amiodarone at 100 mg daily triggers fatal pulmonary toxicity.

Why the study?

Amiodarone pulmonary toxicity can be fatal and occurs even at low doses, posing a diagnostic challenge without specific clinical features.

Design

Case report

Authors

MBMuhammad Imran ButtNHS Highland

Discussion

Member takes

Implication

APT warrants consideration in amiodarone-treated patients with respiratory distress irrespective of dose; single case leaves open need for prospective validation.

Study Design

Type

Case Report (n=1)

Structured PICO

Population

Exposure

Amiodarone started at an initial dose of 600 mg/day and tapered down to a maintenance dose of 100 mg/day over three weeks, continued for 3 years.

Outcome

Amiodarone-induced pulmonary toxicity (APT) leading to fatal respiratory failure.safety

Amiodarone-induced pulmonary toxicity can be fatal even at low maintenance doses (100 mg/day), highlighting the need for close monitoring in high-risk patients.

Limitations

Lung biopsy was not performed due to the risk involved in the procedure

Cite This Study

synapsesocial.com/papers/6ab8d50905ba373fef2973a4 https://doi.org/10.5348/ijcri-201649-cr-10637

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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