Key result
Microinjection of a selective kappa opioid agonist into the hippocampus induced centrally mediated decreases in mean blood pressure and heart rate in both hypertensive and normotensive rats.
Why the study?
Does microinjection of selective mu, delta, and kappa opioid receptor agonists into the hippocampus affect mean blood pressure and heart rate in hypertensive and normotensive rats?
Does microinjection of selective mu, delta, and kappa opioid receptor agonists into the hippocampus affect mean blood pressure and heart rate in hypertensive and normotensive rats?
Hippocampal kappa opioid receptors, but not mu or delta receptors, appear to play a role in central cardiovascular control by mediating hypotensive and bradycardic effects in both hypertensive and normotensive rat models.
Should not change clinical practice; hypothesis-generating for hippocampal kappa opioid modulation of central cardiovascular control.
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Shen et al. (1999) studied Hypertension. Microinjection of selective mu, delta and kappa opioid receptor agonists into the hippocampus vs. Control saline was evaluated on Mean blood pressure and heart rate. Microinjection of a selective kappa opioid agonist into the hippocampus induced centrally mediated decreases in mean blood pressure and heart rate in both hypertensive and normotensive rats.
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