What is the clinical evidence from this study?

Study design: Other. Population: Healthy. Intervention: Dark period vs. Light period. Primary outcome: Mean arterial pressure (MAP).

What question did this study set out to answer?

To establish and evaluate continuous long-term monitoring of circadian mean arterial pressure and heart rate rhythms in catheterized mice.

February 1, 1999AJP Regulatory Integrative and Comparative Physiology

Circadian blood pressure and heart rate rhythms in mice

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Key result

In C57BL mice, mean arterial pressure and heart rate were higher during the dark period (101.4 mmHg and 561.9 beats/min) compared to the light period (93.1 mmHg and 530.3 beats/min).

Population

C57BL mice with carotid arterial catheters

Design

Preclinical

Follow-up

3-6 consecutive days

Authors

PLPing LiFirst Hospital of Lanzhou University SSSteven H. SurWright State University RMRalph E. MistlbergerSimon Fraser University

Discussion

Member takes

Implication

Documents higher active-phase BP/HR in C57BL mice; leaves open extension to genetic hypertension models.

Key Points

To establish and evaluate continuous long-term monitoring of circadian mean arterial pressure and heart rate rhythms in catheterized mice.
Surgically implanted carotid arterial catheters into tethered C57BL mice.
Continuously recorded cardiovascular signals at a sampling rate of 100 Hz across 3 to 6 consecutive days using a computerized system.
Mean arterial pressure displayed a bimodal circadian rhythm, with group mean values of 101.4 ± 7.3 mmHg during the dark period and 93.1 ± 2.9 mmHg during the light period.
Heart rate remained elevated at night compared to daytime levels (561.9 ± 22.7 vs. 530.3 ± 22.3 beats/min), with peaks occurring near dark onset.

Structured PICO

Population

Healthy C57BL mice with carotid arterial catheters monitored continuously for 3-6 days to assess circadian cardiovascular patterns.

Exposure

Continuous cardiovascular monitoring with a computerized system at a sampling rate of 100 Hz

Outcome

Circadian pattern of mean arterial pressure (MAP) and heart rate (HR)surrogate

Main Result

Absolute Event Rate: 101.4% vs 93.1%

Continuous monitoring of circadian cardiovascular parameters is feasible in tethered mice, providing a foundation for investigating genetic models.

Cite This Study

Li et al. (1999) studied Healthy. Dark period vs. Light period was evaluated on Mean arterial pressure (MAP). In C57BL mice, mean arterial pressure and heart rate were higher during the dark period (101.4 mmHg and 561.9 beats/min) compared to the light period (93.1 mmHg and 530.3 beats/min).

synapsesocial.com/papers/6a8aefd0eee946ed63e3a72c https://doi.org/10.1152/ajpregu.1999.276.2.r500

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Circadian blood pressure and heart rate rhythms in mice

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Circadian blood pressure and heart rate rhythms in mice

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider