Key result
Peripheral alpha2CAR-stimulation or AT1R-inhibition restored failing alpha2AAR-mediated auto-inhibition of norepinephrine and epinephrine release and control of total peripheral vascular resistance in spontaneously hypertensive rats.
Why the study?
Does alpha2CAR-stimulation or AT1R-inhibition restore alpha2AAR-mediated auto-inhibition of catecholamine release in spontaneously hypertensive rats?
Population
12-14 weeks old, male normotensive Wistar Kyoto rats and spontaneously hypertensive rats.
Comparison
Pre-treatment with alpha2AR-antagonist, followed… vs Vehicle pre-treatment followed by 15-min…
Design
Preclinical
Follow-up
15 minutes
Authors
Loading...
Should not change hypertension management; hypothesis-generating for alpha2CAR or AT1R modulation in catecholamine control.
Does alpha2CAR-stimulation or AT1R-inhibition restore alpha2AAR-mediated auto-inhibition of catecholamine release in spontaneously hypertensive rats?
Absolute Event Rate: 70.1% vs 27.4%
p-value: p=<0.05
Peripheral alpha2CAR-stimulation or AT1R-inhibition restores failing alpha2AAR-mediated auto-inhibition of catecholamine release and control of total peripheral resistance in spontaneously hypertensive rats.
Torill Berg (2013) studied Hypertension (n=206). alpha2CAR-agonists or AT1R-antagonist vs. Vehicle (PBS) was evaluated on Plasma norepinephrine concentration after 15-min tyramine infusion in SHR (L-659,066 + fadolmidine vs PBS) (p=<0.05). Peripheral alpha2CAR-stimulation or AT1R-inhibition restored failing alpha2AAR-mediated auto-inhibition of norepinephrine and epinephrine release and control of total peripheral vascular resistance in spontaneously hypertensive rats.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: