Why the study?
Does intrarenal infusion of alpha-adrenoceptor antagonists affect renal blood flow and renin release in hypertensive patients?
Population
Hypertensive patients undergoing diagnostic renal angiography (as discussed in the review)
Design
Review
Authors
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Should not alter alpha-blocker use in hypertension; leaves open selective alpha2 targeting for renal hemodynamics.
Does intrarenal infusion of alpha-adrenoceptor antagonists affect renal blood flow and renin release in hypertensive patients?
Alpha 2-adrenoceptors, rather than alpha 1-adrenoceptors, appear to mediate tonic renal vasoconstriction and inhibit renin release in the human kidney.
Michel et al. (1996) studied this question.
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