Key points are not available for this paper at this time.
Regional synaptic protein shifts after ECS in rats should not alter clinical ECT practice; leaves open molecular mechanisms of seizure therapy.
The pattern of changes in brain-specific proteins mainly related to the synapses were studied in rats given electroconvulsive stimuli (ECS). One group was studied after three ECS per week for 4 weeks, another was further allowed a recovery period of 12 weeks. The experimental animals were compared with adequate controls. Brain-specific proteins were analyzed using crossed immunoelectrophoresis. The changes in the protein pattern after 4 weeks of ECS differed in the regions studied and are interpreted as follows: in the hypothalamus the amount of synapses seem to have increased, in the forebrain synaptic remodelling is under way and in the occipital cortex a delay in the neuronal development has been induced. The results further indicate an overall increased preparedness to meet the glycolytic demands accompanying seizure. Following 12 weeks of recovery a partial reversion of the induced changes was observed. The implication of the findings in relation to newer concepts of the working action of electroconvulsive therapy is discussed.
No takes yet. Share an insight, caveat, or question.
Bolwig et al. (1980) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: