Key result
Patients with non-ST elevated myocardial infarction had significantly higher serum levels of MMP-9 and TIMP-1, and lower levels of IL-33 on admission compared to healthy controls.
Why the study?
Are serum levels of IL-33, MMP-9, and TIMP-1 altered in patients with acute coronary syndrome compared to healthy controls?
Observational (n=80)
Are serum levels of IL-33, MMP-9, and TIMP-1 altered in patients with acute coronary syndrome compared to healthy controls?
Absolute Event Rate: 163.14% vs 78.49%
p-value: p=<0.01
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Supports exploration of IL-33/MMP-9/TIMP-1 in NSTEMI; leaves open diagnostic utility without prospective validation.
Güzel et al. (2013) conducted an observational in Acute coronary syndrome (NSTEMI and Unstable Angina) (n=80). Acute coronary syndrome (NSTEMI) vs. Healthy controls without significant coronary artery stenosis was evaluated on Serum matrix metalloproteinase-9 (MMP-9) levels on admission (pg/mL) (p=<0.01). Patients with non-ST elevated myocardial infarction had significantly higher serum levels of MMP-9 and TIMP-1, and lower levels of IL-33 on admission compared to healthy controls.
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