Key result
The AdipoR2 SNP cluster (+795G/A, +870C/A, and +963C/T) was associated with significantly higher plasma adiponectin levels and decreased fasting triglyceride levels in patients with metabolic syndrome.
Why the study?
Are genetic variants of adiponectin receptor 2 associated with improved lipid and inflammatory profiles in patients with metabolic syndrome?
Population
n=20 unrelated German subjects with metabolic syndrome, excluding manifest diabetes or known atherosclerosis.
Comparison
Presence of AdipoR2 SNP cluster vs Absence of AdipoR2 SNP cluster
Design
Cross-sectional
Authors
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AdipoR2 variants may link to better lipids in metabolic syndrome; leaves open causal effects and clinical utility pending prospective data.
Observational (n=20)
Are genetic variants of adiponectin receptor 2 associated with improved lipid and inflammatory profiles in patients with metabolic syndrome?
Absolute Event Rate: 83% vs 176%
p-value: p=0.01
Genetic variants in the AdipoR2 gene are associated with increased adiponectin and decreased triglyceride/VLDL levels, suggesting a role in lipid metabolism.
Broedl et al. (2006) conducted an observational in Metabolic syndrome (insulin resistance and abdominal overweight) (n=20). AdipoR2 SNP cluster (+795G/A, +870C/A, +963C/T) vs. Absence of AdipoR2 SNP cluster was evaluated on Fasting triglycerides (mg/dl) at baseline (p=0.01). The AdipoR2 SNP cluster (+795G/A, +870C/A, and +963C/T) was associated with significantly higher plasma adiponectin levels and decreased fasting triglyceride levels in patients with metabolic syndrome.
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