Key result
In 94 patients with type 2 diabetes, ADIPOR2 (rs16928751) and ADIPOR1 (rs2275737, rs2275738) gene polymorphisms were associated with increased BMI, higher HbA1c levels, and stable hyperglycemia.
Why the study?
The role played by hereditary factors in the development of DM2 has not yet been fully established.
Cross-Sectional (n=94)
Specific polymorphisms in the ADIPOR1 and ADIPOR2 genes are associated with key clinical features of type 2 diabetes, such as increased BMI and hyperglycemia, in the Crimean population.
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Adiponectin polymorphisms may associate with DM2 features; hypothesis-generating and requires validation before any clinical use.
Shramko et al. (2022) conducted a cross-sectional in Diabetes mellitus type 2 (n=94). Adiponectin and adiponectin receptor gene polymorphisms was evaluated on Primary symptoms of DM2 pathogenesis (BMI, HbA1c, hyperglycemia). In 94 patients with type 2 diabetes, ADIPOR2 (rs16928751) and ADIPOR1 (rs2275737, rs2275738) gene polymorphisms were associated with increased BMI, higher HbA1c levels, and stable hyperglycemia.
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