Key result
Expression of TMEV L protein increased apoptotic cell death in BHK-21 cells, while co-expression with L decreased L-induced cell death, suggesting they regulate apoptosis during viral infection.
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The TMEV nonstructural proteins L and L() have opposing effects on apoptosis in BHK-21 cells, suggesting they regulate cell death during viral infection.
Theiler’s murine encephalomyelitis virus is divided into two subgroups, TO and GDVII, inducing subgroup-specific diseases. In order to investigate the role(s) of nonstructural proteins of TMEV, L and L(∗), leaders of two subgroups, were separately expressed with or without L(∗) in BHK-21 cells. Expression of L increased the number of apoptotic cells. L(∗)/BHK-21 cells constitutively expressing L(∗) showed the decrease in cell death induced by L. These results suggest that L and L(∗) regulate apoptosis during viral infection and contribute to TMEV subgroup-specific biological activities.
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Okuwa et al. (2010) studied Theiler's murine encephalomyelitis virus infection. Expression of L and L proteins vs. Without L was evaluated on Apoptotic cell death. Expression of TMEV L protein increased apoptotic cell death in BHK-21 cells, while co-expression with L decreased L-induced cell death, suggesting they regulate apoptosis during viral infection.
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