Population
DA strain of Theiler's murine encephalomyelitis virus
Comparison
In vivo passage in mouse brain vs Tissue culture passage
Design
Preclinical
Authors
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No immediate implications for human CNS infection; hypothesis-generating for TMEV variant effects on neurovirulence.
Genomic differences in virus variants during acute in vivo passage may determine the biological behavior and neurovirulence of the DA strain of Theiler's murine encephalomyelitis virus.
Roos et al. (1984) studied this question.
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