June 1, 1991Clinical and Experimental Pharmacology and Physiology

Distribution and Inhibition of Neutral Metalloendopeptidase (Nep) (Ec 3.4.24.11), the Major Degradative Enzyme for Atrial Natriuretic Peptide, in the Rat Kidney

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Population

Rat kidney

Design

Preclinical

Authors

MKMasayuki KanazawaTohoku University CJColin I. JohnstonGeneral Cardiology

Discussion

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Implication

Preclinical renal NEP mapping in rats; leaves open relevance to human ANP-targeted therapies.

Structured PICO

Population

Rat kidney

Intervention

Specific NEP inhibitors (SCH39370, phosphoramidon and thiorphan) at micromolar concentrations

Outcome

Regional distribution of NEP activity and its inhibitionsurrogate

This preclinical study maps the regional distribution of NEP in the rat kidney, suggesting ANP degradation occurs mainly in the proximal tubules of juxtamedullary nephrons.

Cite This Study

Kanazawa et al. (1991) studied this question.

synapsesocial.com/papers/6a8afb2c2ff0ab4f91e94bb5 https://doi.org/10.1111/j.1440-1681.1991.tb01477.x

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Distribution and Inhibition of Neutral Metalloendopeptidase (Nep) (Ec 3.4.24.11), the Major Degradative Enzyme for Atrial Natriuretic Peptide, in the Rat Kidney

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Distribution and Inhibition of Neutral Metalloendopeptidase (Nep) (Ec 3.4.24.11), the Major Degradative Enzyme for Atrial Natriuretic Peptide, in the Rat Kidney

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider