Key result
Myocardial infarction after cardiac transplantation in rats increased ADAM8 expression compared with controls (1.9 vs 1.0) at 48 hours.
Why the study?
Does myocardial infarction combined with ischemia-reperfusion injury increase ADAM8 expression and inflammatory remodeling compared to ischemia-reperfusion injury alone in a rat cardiac transplantation model?
Population
48 Fischer 344 rats undergoing isogenic heterotopic cardiac transplantation after cardiac arrest
Comparison
Ischemia-reperfusion injury with early regional… vs Ischemia-reperfusion injury alone, and Controls
Design
Preclinical
Follow-up
up to 48 hours
Authors
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May signal global MI effects on ADAM8 in rat transplants; hypothesis-generating for human remodeling studies.
Does myocardial infarction combined with ischemia-reperfusion injury increase ADAM8 expression and inflammatory remodeling compared to ischemia-reperfusion injury alone in a rat cardiac transplantation model?
Effect estimate: 1.9 fold increase
Absolute Event Rate: 1.9% vs 1%
Myocardial infarction combined with ischemia-reperfusion injury in a rat model increases remote ADAM8 expression and inflammatory remodeling, suggesting a global myocardial impact of MI.
Vuohelainen et al. (2011) studied Myocardial infarction and ischemia-reperfusion injury (n=48). Myocardial infarction (LAD ligation) after cardiac transplantation vs. Ischemia-reperfusion injury alone and Controls was evaluated on ADAM8 expression at 48 h (1.9 fold increase). Myocardial infarction after cardiac transplantation in rats increased ADAM8 expression compared with controls (1.9 vs 1.0) at 48 hours.
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