August 13, 2007Heart
Sudden coronary death, fatal acute myocardial infarction and widespread coronary and myocardial inflammation
Population
72 autopsy cases: 12 dying of sudden coronary death, 12 dying <4 weeks after acute myocardial infarction, 12…
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
T-lymphocyte infiltrates across ACS stages may signal immune involvement; leaves open whether targeting them affects outcomes.
Structured PICO
P
Population
72 autopsy cases: 12 dying of sudden coronary death, 12 dying <4 weeks after acute myocardial infarction (AMI), 12 dying >4 months after AMI, 12 with active lymphocytic myocarditis, 12 with hypertensive heart disease, and 12 control subjects.
C
Comparator
Patients with myocarditis, patients with hypertensive heart disease, and control subjects
O
Outcome
Number of activated T-lymphocytes (CD3+/DR+) in the myocardium and coronary artery wall, and intercellular adhesion molecule-1 (ICAM-1) expression in the myocardiumsurrogate
Widespread lymphocytic infiltration and a proinflammatory phenotype shift occur in both coronary arteries and myocardium in patients dying from acute coronary syndromes.
Cite This Study
Abbate et al. (2007) studied this question.