Key result
TRPV1 receptors, localized on primary sensory neurons, vascular smooth muscle cells, and endothelial cells, play a complex role in vasoregulation, blood pressure homeostasis, and cardiovascular reflexes.
Why the study?
The physiological role and pharmacological exploitation of non-neural TRPV1 receptors are not well understood, despite accumulating experimental findings.
Understanding the non-neuronal expression and function of TRPV1 receptors in vasoregulation may provide novel pharmacological targets for managing blood pressure and cardiovascular diseases.
TRPV1's complex vasoregulatory roles advise against clinical targeting; leaves open precise therapeutic windows for research.
Transient Receptor Potential V1 (TRPV1) receptor is under investigation for several decades to develop a sensory neuron specific analgesic substance, but in contrary of the intense effort success is awaiting. A pile of experimental results gathered about the non-neural location of TRPV1 receptor in the last two decades. The physiological role of these receptor locations is not well understood and the pharmacological exploitation is not elaborated. The present review focuses on the role of TRPV1 receptors in vasoregulation and blood pressure homeostasis including Bezold-Jarisch reflex, baroreflex sensitivity, sensory neuron dependent vasodilation, endothelial cell mediated vasomotion, arteriolar Smooth Muscle Cell (SMC) related vasoconstriction and visualization of TRPV1 receptors on SMCs by reporter mice.
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Róbert Pórszász (2020) conducted a review in Vasoregulation and blood pressure homeostasis. TRPV1 receptor activation and antagonism was evaluated. TRPV1 receptors, localized on primary sensory neurons, vascular smooth muscle cells, and endothelial cells, play a complex role in vasoregulation, blood pressure homeostasis, and cardiovascular reflexes.
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