Why the study?
Is the renin-angiotensin-aldosterone system significantly activated in patients with renovascular hypertension?
Population
19 patients with renovascular hypertension (14 with benign hypertension, 5 with malignant hypertension)
Comparison
Surgical intervention (in a subset of patients) vs Preoperative baseline
Design
Cohort
Authors
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Questions overt RAAS activation as sole driver in benign renovascular hypertension; hypothesis-generating for alternative mechanisms in larger cohorts.
Is the renin-angiotensin-aldosterone system significantly activated in patients with renovascular hypertension?
The findings suggest that blood pressure elevation in benign renovascular hypertension cannot be solely explained by overt activation of the renin-angiotensin-aldosterone system.
Theodore A. Kotchen (1970) studied this question.
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