Why the study?
How do plasma renin activity and renin-substrate concentration differ between patients with liver disease and normal subjects?
Population
Patients with liver disease and normal ambulatory subjects, all on an unrestricted sodium intake.
Design
Case-control
Authors
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May inform ascites evaluation in cirrhosis; hypothesis-generating for renin modulation, needs prospective validation.
How do plasma renin activity and renin-substrate concentration differ between patients with liver disease and normal subjects?
Patients with cirrhosis and ascites exhibit markedly elevated plasma renin activity but decreased renin-substrate concentration compared to normal subjects.
Carlos R. Ayers (1967) studied this question.
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