Key result
Plasma big endothelin-1 was an independent predictor of severe coronary artery calcification (CACS >400) with an odds ratio of 1.721.
Why the study?
Does plasma bigET-1 level predict the severity of coronary artery calcification in patients undergoing CCTA for chest pain?
Population
428 consecutive patients undergoing coronary computed tomography angiography due to stable typical or…
Design
Cross-sectional
Authors
Loading...
Should not yet change CAC assessment in chest pain; hypothesis-generating for bigET-1 and requires prospective validation.
Cross-Sectional (n=428)
No
Does plasma bigET-1 level predict the severity of coronary artery calcification in patients undergoing CCTA for chest pain?
Odds Ratio: 1.721 (95% CI 1.002–2.956)
p-value: p=0.049
Plasma bigET-1 levels are independently associated with severe coronary artery calcification (CACS >400) in patients with chest pain, suggesting its potential utility as a circulating biomarker for assessing CAC severity.
Wang et al. (2018) conducted a cross-sectional in Coronary Artery Calcification (n=428). Plasma big endothelin-1 (bigET-1) vs. Low bigET-1 levels was evaluated on Presence of CACS >400 (OR 1.721, 95% CI 1.002-2.956, p=0.049). Plasma big endothelin-1 was an independent predictor of severe coronary artery calcification (CACS >400) with an odds ratio of 1.721.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: