Key result
Analysis of DHPR-RyR coupling in rat ventricular myocytes revealed a DHPR mean open time of ~0.5 ms and RyR activation time constant of ~0.6 ms, with low coupling fidelity that increased with BayK 8644.
Control of calcium release intensity by physiological stimuli can be achieved by modulating the number and duration of DHPR openings at low coupling fidelity, avoiding inadvertent triggering of calcium release events.
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Low-fidelity DHPR-RyR coupling in rat myocytes supports modulation of Ca²⁺ release via DHPR openings; leaves open translation to human physiology.
Polaková et al. (2008) studied Rat ventricular myocytes. DHPR calcium current triggers and BayK 8644 was evaluated on DHPR-RyR coupling fidelity and probability of calcium release activation. Analysis of DHPR-RyR coupling in rat ventricular myocytes revealed a DHPR mean open time of ~0.5 ms and RyR activation time constant of ~0.6 ms, with low coupling fidelity that increased with BayK 8644.
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