Key result
Systematic evaluation should exclude alternative etiologies before referring moderate mixed aortic valve disease for AVR.
Patients with moderate mixed aortic valve disease and symptoms or LV dysfunction require systematic evaluation to exclude other causes before proceeding to aortic valve replacement.
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Urges exclusion of alternative causes before AVR referral in symptomatic moderate MAVD; leaves open prospective validation of this framework.
Differential diagnosis framework for evaluating patients with moderate mixed aortic valve disease (MAVD). When patients with moderate MAVD present with symptoms or left ventricular (LV) dysfunction [ejection fraction (EF) < 50%], a systematic evaluation should exclude alternative aetiologies before attributing their presentation to their valve disease and referring patients for aortic valve replacement (AVR).
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Yogeswaran et al. (2025) conducted a review in Moderate mixed aortic valve disease (MAVD). Systematic evaluation to exclude alternative aetiologies was evaluated. A systematic evaluation should exclude alternative aetiologies before attributing symptoms or left ventricular dysfunction to moderate mixed aortic valve disease and referring for valve replacement.
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