Key result
In vaccinated animals, most antibodies were directed against antigenic site 2 (76% of cattle, 65% of sheep, and 58% of pigs), implying it is a dominant neutralization immunogenic site.
Population
Vaccinated animals (cattle, sheep, and pigs)
Design
Preclinical
Authors
Loading...
Supports site 2-focused FMDV vaccines in livestock; hypothesis-generating across species, requires efficacy validation.
Antigenic site 2 is a dominant neutralization immunogenic site in serotype O FMDV across cattle, sheep, and pigs, making it a strong candidate for novel vaccine design.
Mahapatra et al. (2011) studied Foot-and-mouth disease virus (FMDV) vaccination response. FMDV vaccination was evaluated on Relative use of known binding sites by polyclonal antibodies. In vaccinated animals, most antibodies were directed against antigenic site 2 (76% of cattle, 65% of sheep, and 58% of pigs), implying it is a dominant neutralization immunogenic site.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: