Key result
Recovered FMDV containing mutations at VP2-74 and VP2-191 exhibited greater resistance to neutralization with guinea pig and bovine antisera than a virus engineered with mutations at five known sites.
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Mutations at VP2-74/191 may enhance FMDV escape; hypothesis-generating for antigenic site prioritization in livestock vaccines.
Asfor et al. (2014) studied Foot-and-mouth disease. Site-directed mutagenesis of FMDV capsid (VP2-74, VP2-191, VP3-85) vs. Wild-type FMDV O1K and 5-site mutant virus was evaluated on Reduction in virus-neutralizing antibody (VN) titre. Recovered FMDV containing mutations at VP2-74 and VP2-191 exhibited greater resistance to neutralization with guinea pig and bovine antisera than a virus engineered with mutations at five known sites.
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