November 3, 2017VaccineOpen Access

Evaluation of a polyvalent foot-and-mouth disease virus vaccine containing A Saudi-95 against field challenge on large-scale dairy farms in Saudi Arabia with the emerging A/ASIA/G-VII viral lineage

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Foot-and-mouth disease. Intervention: Polyvalent foot-and-mouth disease virus vaccine containing A Saudi-95. Primary outcome: Incidence risk of foot-and-mouth disease.

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Key result

During a foot-and-mouth disease outbreak on vaccinated dairy farms, incidence risk ranged from 2.6% to 20.1% and was significantly higher among youngstock (18.7%) compared to adults (7.4%).

Population

Dairy cattle on four large-scale dairy farms experiencing outbreaks and one related farm with no history of…

Design

Cohort

Authors

NLNicholas A. LyonsFood and Agriculture Organization of the United Nations ALAnna B. LudiOak Ridge Associated Universities GWGinette WilsdenThe Pirbright Institute

Discussion

Member takes

Implication

Variable FMD vaccine performance in outbreaks, higher in youngstock, warrants age-specific caution; leaves open validation of field correlates of protection.

Study Design

Type

Observational

Multicenter

Yes

Structured PICO

Population

Animals on four large-scale dairy farms in Saudi Arabia using routine vaccination during a foot-and-mouth disease outbreak.

Exposure

Polyvalent foot-and-mouth disease virus vaccine containing A Saudi-95

Outcome

Incidence risk of foot-and-mouth disease among exposed groups and vaccine-induced neutralisation titressurrogate

Analysis of field data from FMD outbreaks provides a realistic estimation of expected vaccine performance and highlights the need to validate correlates of protection in field conditions.

Limitations

An estimate of vaccination effectiveness was not possible on the affected farms
Findings regarding the effectiveness of local isolation and the occurrence of subclinical infection require further evaluation
Further work is necessary to validate correlates of protection in field conditions
Further evaluation required for local vs whole group isolation and subclinical infection

Cite This Study

Lyons et al. (2017) conducted an observational in Foot-and-mouth disease. Polyvalent foot-and-mouth disease virus vaccine containing A Saudi-95 was evaluated on Incidence risk of foot-and-mouth disease. During a foot-and-mouth disease outbreak on vaccinated dairy farms, incidence risk ranged from 2.6% to 20.1% and was significantly higher among youngstock (18.7%) compared to adults (7.4%).

synapsesocial.com/papers/6a8b179f2ff1fb71e1e3a310 https://doi.org/10.1016/j.vaccine.2017.10.029

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Implication

Variable FMD vaccine performance in outbreaks, higher in youngstock, warrants age-specific caution; leaves open validation of field correlates of protection.

Evaluation of a polyvalent foot-and-mouth disease virus vaccine containing A Saudi-95 against field challenge on large-scale dairy farms in Saudi Arabia with the emerging A/ASIA/G-VII viral lineage

Discussion

Member takes

Implication

Study Design

Structured PICO

Limitations

Cite This Study

Evaluation of a polyvalent foot-and-mouth disease virus vaccine containing A Saudi-95 against field challenge on large-scale dairy farms in Saudi Arabia with the emerging A/ASIA/G-VII viral lineage

Discussion

Member takes

Implication

Study Design

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider