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February 26, 1988JAMA

Dipyridamole-Induced Myocardial Ischemia

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Why the study?

Does oral dipyridamole induce myocardial ischemia in patients awaiting coronary artery bypass surgery?

Population

453 patients hospitalized for coronary artery bypass surgery

Design

Case_series

Follow-up

2 days

Authors

RCRamón CastellóMemorial Hospital

Discussion

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Implication

May induce ischemia in some CABG candidates; hypothesis-generating and should not yet change practice.

Structured PICO

Does oral dipyridamole induce myocardial ischemia in patients awaiting coronary artery bypass surgery?

P
Population
453 patients hospitalized for coronary artery bypass surgery
I
Intervention
Oral dipyridamole 100 mg four times a day for the two days before surgery
O
Outcome
Exacerbation of angina and ischemic changes on electrocardiogramssafety

Oral dipyridamole administration before coronary artery bypass surgery can induce angina and ischemic ECG changes in a small percentage of patients.

Cite This Study

Ramón Castelló (1988) studied this question.

synapsesocial.com/papers/6a8b188cf71b672e3df46759https://doi.org/10.1001/jama.1988.03720080015009
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dipyridamole-lnduced Myocardial Ischemia1987 · 34 citations
  2. 2Acute effect of intravenous dipyridamole on regional coronary hemodynamics and metabolism.1981 · 133 citations
  3. 3Dipyridamole Test in Angina Pectoris: Diagnostic Value and Pathophysiological Implications2008 · 36 citations
  4. 4A Platelet-Inhibitor-Drug Trial in Coronary-Artery Bypass Operations1982 · 540 citations
  5. 5Effect of Coronary Vasodilator Drugs on Retrograde Flow in Areas of Chronic Myocardial Ischemia1964 · 287 citations