Key result
Most multiple sclerosis patients, but not diabetes patients, exhibited T cell immunity targeting a specific cow milk protein epitope, BSA(193), which also induced encephalitis in mice.
The identification of a specific cow milk protein epitope, BSA(193), targeted by T cells in MS patients and capable of inducing encephalitis in mice, provides a potential immunological mechanism linking dairy consumption to MS risk through antigenic mimicry.
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Does not support altering dairy intake in MS; hypothesis-generating for BSA(193) mimicry and requires prospective human validation.
Winer et al. (2001) studied Multiple sclerosis. Cow milk protein (CMP) / BSA(193) vs. Diabetes patients was evaluated on T cell immunity to CMPs and BSA(193). Most multiple sclerosis patients, but not diabetes patients, exhibited T cell immunity targeting a specific cow milk protein epitope, BSA(193), which also induced encephalitis in mice.
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