Why the study?
Does the dosing time of enalapril influence the daily variation of pulmonary function in healthy male adults?
Does the dosing time of enalapril influence the daily variation of pulmonary function in healthy male adults?
A single dose of enalapril administered in the morning or evening does not significantly alter the daily variation of pulmonary function in healthy subjects.
No adjustment of enalapril dosing time needed for pulmonary function; confirms neutral effect on daily peak expiratory flow variation in healthy adults.
This study was performed to determine the influence of dosing time of enalapril, an angiotensin-converting enzyme. inhibitor, on pulmonary function. Enalapril (10 mg) or placebo was given orally at 10: 00 and 22: 00 to eight healthy, nonsmoking, male adults in a randomized, double-blind crossover design. Peak expiratory flow (PEF) was determined at 16: 00 on day 1 and 04: 00 and 16: 00 on day 2. PEF at 04: 00 was significantlylower than that at 16: 00 (p<0.01). Enalapril dosed at 10: 00 or 22: 00 did not signifi cantly influence the daily variations of PEF compared to placebo. The daily variation of pulmonary function might not be influenced by a single dosing of enalapril in the morning or evening.
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Sugimoto et al. (2000) studied this question.
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