Key result
Short oligonucleotides offer a promising strategy for targeting RNA, specifically Group I introns in pathogens like Pneumocystis carinii and Candida albicans, by improving cellular uptake and selectivity.
Population
Group I introns from the mammalian pathogens Pneumocystis carinii and Candida albicans
Design
Review
Authors
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Should not yet change antifungal practice; leaves open clinical translation of short oligonucleotides for Group I introns.
Short oligonucleotides present a promising strategy for targeting RNA, specifically Group I introns in fungal pathogens, potentially overcoming challenges of cellular uptake and binding selectivity.
Disney et al. (2003) conducted a review in Fungal infections (Pneumocystis carinii and Candida albicans). Short oligonucleotides targeting RNA was evaluated. Short oligonucleotides offer a promising strategy for targeting RNA, specifically Group I introns in pathogens like Pneumocystis carinii and Candida albicans, by improving cellular uptake and selectivity.
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