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April 1, 1993AJP Renal Physiology

Cloning of a rabbit kidney cortex AT1 angiotensin II receptor that is present in proximal tubule epithelium

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Population

Rabbit proximal tubule cells, rat and rabbit kidney cortical membranes, rabbit kidney cortex cDNA library…

Design

Preclinical

Authors

KBKevin D. BurnsUniversity of OttawaTITadashi InagamiHeart Failure / CardiomyopathyRHRaymond C. HarrisKanazawa University

Discussion

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Overview

No immediate clinical implications; confirms single AT1 gene and predominant AT1 binding in rabbit proximal tubule.

Structured PICO

P
Population
Rabbit proximal tubule (PT) cells, rat and rabbit kidney cortical membranes, rabbit kidney cortex cDNA library, transfected COS-1 cells, mouse PT line (MCT), and rat glomerular mesangial cells
I
Intervention
Cloning and characterization of the rabbit proximal tubule AT1 angiotensin II receptor
O
Outcome
Receptor binding properties, cDNA sequence, and mRNA expression levelssurrogate

The study successfully cloned the rabbit proximal tubule AT1 angiotensin II receptor, confirming its presence and single-gene origin in rabbits.

Cite This Study

Burns et al. (1993) studied this question.

synapsesocial.com/papers/6a8b268fe6afc07dcbf45002https://doi.org/10.1152/ajprenal.1993.264.4.f645
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin II upregulates type-1 angiotensin II receptors in renal proximal tubule.1995 · 146 citations
  2. 2Localization of angiotensin II type 1 receptor subtype mRNA in rat kidney1995 · 32 citations
  3. 3Molecular Cloning of AT1 Angiotensin Receptors1992 · 62 citations
  4. 4Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.1993 · 716 citations
  5. 5Immunohistochemical localization of ANG II AT1 receptor in adult rat kidney using a monoclonal antibody1997 · 256 citations