April 1, 1995American Journal of Hypertension

Attenuated Ca2+ Response to Acetylcholine in Endothelial Cells From Aorta of Aldosterone-Salt Hypertensive Rats

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Population

Aldosterone-salt hypertensive rats (AHR) and age-matched control-salt rats (CSR)

Comparison

Acetylcholine vs Age-matched control-salt rats (CSR)

Design

Preclinical

Authors

YLYi LiuNingbo University

Discussion

Member takes

Implication

Depressed endothelial calcium responses may mediate impaired relaxation in aldosterone hypertension; leaves open relevance to human disease mechanisms.

Structured PICO

Population

Aldosterone-salt hypertensive rats (AHR) and age-matched control-salt rats (CSR)

Intervention

Acetylcholine (to induce endothelium-dependent relaxation and Ca2+ response)

Comparator

Age-matched control-salt rats (CSR)

Outcome

Endothelium-dependent relaxation and free Ca2+ ([Ca2+]i) response in endothelial cellssurrogate

Impaired endothelium-dependent relaxation in aldosterone-salt hypertensive rats is associated with depressed endothelial intracellular calcium responses to acetylcholine.

Cite This Study

Yi Liu (1995) studied this question.

synapsesocial.com/papers/6a8b2855c716e89f35ded846 https://doi.org/10.1016/0895-7061(94)00205-p

Topics

Hypertension management

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Implication

Depressed endothelial calcium responses may mediate impaired relaxation in aldosterone hypertension; leaves open relevance to human disease mechanisms.

Attenuated Ca2+ Response to Acetylcholine in Endothelial Cells From Aorta of Aldosterone-Salt Hypertensive Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Attenuated Ca2+ Response to Acetylcholine in Endothelial Cells From Aorta of Aldosterone-Salt Hypertensive Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider