Key result
In rat aortic smooth muscles, lower concentrations of ET-1 involve a Ca2+ entry channel sensitive to SK&F 96365 and LOE 908, whereas higher concentrations also involve a channel resistant to LOE 908.
Population
Rat thoracic aortic rings and single smooth muscle cells
Design
Preclinical
Authors
Loading...
Does not guide clinical ET-1 targeting; leaves open concentration-specific Ca2+ channel roles in vascular smooth muscle.
Endothelin-1 induces rat aortic smooth muscle contraction via distinct calcium entry channels depending on concentration, utilizing NSCC-2 at low concentrations and additionally recruiting SOCC at higher concentrations.
Zhang et al. (1999) studied this question. SK&F 96365 and LOE 908 was evaluated on Contractions and increases in intracellular free Ca2+ concentration. In rat aortic smooth muscles, lower concentrations of ET-1 involve a Ca2+ entry channel sensitive to SK&F 96365 and LOE 908, whereas higher concentrations also involve a channel resistant to LOE 908.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: