Key result
PAI-1 gene polymorphisms (-844 G/A and -675 4G/5G) showed no significant differences in genotype or allelic frequency between Kawasaki disease patients and normal controls.
Why the study?
Is there an association between PAI-1 promoter gene polymorphisms and Kawasaki disease or its coronary complications?
Case-Control (n=262)
Yes
Is there an association between PAI-1 promoter gene polymorphisms and Kawasaki disease or its coronary complications?
Polymorphisms in the PAI-1 promoter region (-844 G/A and -675 4G/5G) do not appear to be associated with the pathogenesis of Kawasaki disease or the development of coronary artery lesions.
Answers are grounded in this paper and cite their sources.
PAI-1 polymorphisms should not guide Kawasaki disease risk assessment; hypothesis-generating and requires validation in larger cohorts.
Purpose : To demonstrate genetic background of pathogenesis of Kawasaki disease (KD), I examined the genetic polymorphism of plasminogen activator inhibitor-1 (PAI-1) in KD patients. Methods : PCR-RFLP of PAI- 1 promotor gene was analyzed in 56 KD patients admitted to Kyunghee University Hospital, Gachon Medical School Gil Hospital, and Eulji Hospital from March to August 2000 and 206 normal control populations. Results : There were no differences in the genotype and allelic frequency of the PAI-1-675 (4G/5G) and PAI-1-844 (G/A) polymorphic site (which are located in the promoter region) between KD and control subjects. Also I could not detect any significant differences in specific genotypes between patients with the coronary artery lesion (CAL) and patients without CAL. Conclusion : No association was observed in -844 G/A and -675 4G/5G of PAI-1 gene polymorphism with KD.
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Mi Young Han (2007) conducted a case-control in Kawasaki disease (n=262). PAI-1 gene polymorphism (-844 G/A and -675 4G/5G) vs. Normal control populations was evaluated on Genotype and allelic frequency of the PAI-1-675 (4G/5G) and PAI-1-844 (G/A) polymorphic sites. PAI-1 gene polymorphisms (-844 G/A and -675 4G/5G) showed no significant differences in genotype or allelic frequency between Kawasaki disease patients and normal controls.
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